Trimix Injections for Effective Erectile Function

Trimix is a common term used to describe a mixture of Papaverine, Phentolamine, and Alprostadil (PGE). Each of these drugs produces a vasodilating effect when injected into the penis. The injection is done using a very small needle, inserted into the proper area along the shaft of the penis, so the drug mixture is delivered right into the erectile tissue (corpus cavernosum).

The mixture of drugs causes the corpus cavernosum to relax, dilate, and become filled with blood, producing an erection. Trimix therapy is recognized as a viable treatment for erectile dysfunction by the American Urological Society.

Trimix is a prescribed, injectable medication consisting of active ingredients that help to relax, expand, and fill the erectile tissue with blood resulting in an erection shortly after administration.

Unlike oral medications (Viagra, Levitra, and Cialis), Trimix is localized to the intended area rather than having to flow through the bloodstream into other areas of the body. Trimix is self-administered and easy to perform in the comfort of your home.

What is erectile dysfunction?

Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection sufficient for sexual intercourse. While erectile dysfunction can affect men of any age, it is most common in men over the age of 40. Studies have estimated that the number of men suffering from erectile dysfunction in the United States is more than 30 million.

Symptoms and Causes of ED

The inability to achieve or maintain an erection can affect a man at any time. It can happen once in a while, or more frequently, and there can be many different causes. Some common causes include:

  • low testosterone;
  • cardiovascular disease;
  • diabetes;
  • prostate issues;
  • depression;
  • anxiety;
  • nerve/spinal cord damage;
  • effects of taking medications.

Trimix injection is a medication that is very customizable to the patient’s needs. In order to receive the most effective results, it is imperative that the patient, provider, and pharmacy work together in determining the correct formula.

Be aware that it is possible that the first few administrations may not deliver the individual’s satisfactory result. Increasing the dosage little by little will help reach the individual patient’s goal. To do this, the initial dose should be 0.05cc (mL) to 0.2cc (mL) depending on the level of the patient’s ED. Max dose is 0.50cc (mL). Always contact a doctor before increasing your dosage.

Indications to Trimix

Trimix is indicated in the treatment of men with erectile dysfunction. This injectable medication is perfect for patients unsuitable for the oral medication prostaglandin E1.

What is contained in the 3 medications combined to form this sterile injection?

Papaverine: This is a vasodilator that helps to expand the blood vessels. When injected into the penile tissue, this medication causes the smooth muscles to relax. In turn, this allows blood to flow through the corpus cavernosum resulting in an erection.

Alprostadil: Also known as prostaglandin E1 (PGE1), alprostadil is a naturally occurring prostaglandin used as a medication. This medication is also within the vasodilator class. It is also used to help open the blood vessels by relaxing the smooth muscles within the penis. Alprostadil is listed on the World Health Organization’s List of Essential Medicines and was isolated in 1957 and approved for medical use in the United States in 1981.

Phentolamine: This medication is a reversible nonselective a-adrenergic antagonist. Its primary action is vasodilation. Because it is a nonselective a-blocker, this medication also increases cardiac output.

Trimix is generally an effective, low-cost treatment, especially for those patients who have not had good results or experience moderate to severe side effects from PDE5 inhibitors (oral medication).

Trimix injections offer a solution for ED that is:

  • safe;
  • reliable;
  • fast-acting;
  • long-lasting;
  • more affordable than oral medications;
  • not affected by alcohol consumption.

Trimix medication can provide longer and fuller erections that may last through the climax, allowing you to maintain and improve your sexual health. An intracavernous injection is the most effective non-surgical treatment for ED, according to the American Urologic Association. Penile injections, unlike most oral medications, can trigger an automatic erection in less than 5 minutes.


The use of Trimix injection is contraindicated in patients with allergies to any components in this medication, sickle cell anemia, blood clotting disorders, any condition that can predispose you to priapism (a painful erection lasting more than 4 hours), leukemia, anatomical deformations of the penis, penile implants, and if you have direct instructions from your physician to abstain from sexual activity.

It is important to provide a doctor with a list of all drugs that you are currently using. This includes all non-prescription drugs, illegal drugs, herbal, and dietary supplements. Some chemicals within Trimix can interact with your medication causing them to become ineffective or leave you with adverse effects.

While using Trimix, if you experience any swelling, numbness, tenderness, redness, and lumps on your penis or its surrounding areas, make sure to contact a doctor immediately.

For getting a free consultation concerning the use of Trimix or other ED treatment methods, please get in touch with our experts here.